The Bradshaw Collection contains books published 1601-1700 and is notable for its English Revolution, or Civil War, tracts, of which there are about sixty mostly describing local events, such as The Taking of Gateshead Hill: and blocking up of Newcastle … (1644), A Terrible and bloudy fight at Tinmouth Castle on Fryday last … (1648) and The King's declaration at Newcastle concerning his refusall to come to the parliament of England … (1647). Some of these are illustrated, often with wood-cut portraits.Other subjects represented in the collection include theology and some literature. Classical works, in Latin and Greek, by such authors as Catullus, Pliny, Virgil and Juvenal; Aristophanes, Dionysius and Euripides make up a large portion of the collection. The collection also has volume I of Edmund Gibson's English translation of William Camden's Britannia (1695), the first (Latin) edition of which had been the first comprehensive study of Britain.

The Pybus Collection, originally brought together by the esteemed local medic and surgeon Professor Frederick Charles Pybus (1883-1975), is rich in material relating to the history of medicine. The collection consists chiefly of some 2000 volumes which are mostly classics of the history of medicine, with particular reference to anatomy, surgery and medical illustration.

Highlights are Gilles de Corbeil's De Pulsibus (1494), the first printed book on the pulse, as well as a 1648 edition of William Harvey's celebrated work Exercitatio anatomica de motu cordis et sanguinis in which he published his discoveries about the motion of the heart and blood. There is also a 1555 edition of one of the most important and influential books in the history of medicine, De Humani Corporis Fabrica by Andreas Versalius. Most of the other celebrated anatomists are represented here too, as well as later pioneers and experts.

The Pybus collection also includes engravings, portraits, busts, holographic letters and a set of bleeding bowls (currently housed at the Walton Library).

This collection represents the historical portion of the Library of Appleby Grammar School in Cumbria (formerly in the old county of Westmorland) and has been deposited on indefinite loan. The nucleus of the collection was the personal library of an early headmaster of the school, Reginald Bainbrigg [1545-1612?].Books in this collection range in publication date from the Fifteenth Century to the Twentieth Century. The collection can be searched on the library's catalogue and there is also a printed catalogue by the late Edgar Hinchcliffe, formerly a master at the school, available from the Special Collections reading room.The collection contains predominantly classical, theological, literary and historical works, as well as a number of early sixteenth-century English bindings. There are many sixteenth-century editions of works by classical authors, such as Cicero, while other highlights include several works by the English philosopher and enlightenment thinker John Locke and a 1561 Basel imprint of Martin Luther's Quaestionum Sacrarum.

This is a collection of chiefly historical medical texts, numbering about 450 volumes, along with some archival material which was formerly owned by the neurologist and medical historian, Edwin Clarke (1919-1996). The collection usefully complements the Pybus and the Medical Collections.

Highlights include An inquiry concerning the history of the cowpox: principally with a view to supersede and extinguish the smallpox (1798) by George Pearson, the well-known physician, chemist and early advocate of Jenner's cowpox vaccination; and the Report from the Committee appointed to examine the physicians who have attended His Majesty, during his illness: touching the present state of His Majesty's health (1789), issued by Parliament during the period of King George III's recurrent mental illness. The collection also contains some modern secondary texts on various aspects of the history of medicine.

The White Collection, named after Robert White (1802-1874) was presented to King's College (now Newcastle University) by his great nephew George White Pickering. It is a rich source of literature as well as being strong in ecclesiastical and local history such as James Raine's writings on local history and antiquities.

There are works by John Dryden, William Hazlitt, Thomas Hood, James Thomson, Robert Burns, Mark Akenside, Thomas Chatterton, John Gay, H.W. Longfellow, Matthew Prior, John Keats, John Milton, James Hogg, John Clare, Edgar Allan Poe, George Herbert, William Cowper, Thomas Gray and the poems of Ossian as well as several works by S.T. Coleridge, including Aids to reflection (1848), Biographia literaria (1817), Confessions of an inquiring spirit (1849) and The friend (1850). Alongside the work of these distinguished authors sit English and Scottish ballads, garlands and chapbooks including some which were printed in Newcastle.

The Cowen Tracts are almost two thousand pamphlets which were formerly owned by local (radical) M.P., Joseph Cowen (1829-1900). The tracts date mostly from the mid- to late-Nineteenth Century and reflect Cowen's interest in the social, educational, political and economic issues of the day.

There is some earlier material, such as Deed of incorporation for the insurance of ships printed by T. Angus, St. Nicholas' Church-Yard, Newcastle (1778). Pamphlets were an effective form of public debate because they could be circulated to a wider audience than books and authors could remain anonymous. The Cowen Tracts discuss Irish politics, foreign policy, women's rights, religion, education and public health and include such titles as The Union programme for 1880: constructive, not destructive, Irish legislation [1879?], Are women fit for politics?: are politics fit for women [185-] and The education of the agricultural labourer: a paper read before the Morpeth Chamber of Agriculture, on Wednesday, Feb. 2, 1870 by M.W. Ridley (1870).

Contains of 2 albums of letters, including some by people of local significance like Thomas Bewick, Richard Grainger, George Stephenson, George Otto Trevelyan, Robert Spence Watson and Joseph Swan and others written by such household names as A.E. Houseman, Horatio Nelson, Isambard Kingdom Brunel, William Wilberforce, Michael Faraday, William Ewart Gladstone, Thomas Carlyle, Walter Besant, Mary Shelley, Charles Babington, Garibaldi, Victor Hugo, Ellen Terry and Robert Southey. Other letters include a request for an address to facilitate the delivery of a bear skin from David Walton (1859), an account of the pranks of the 'Borrowlow Bogle' from J. Arkle (1856), the refusal to grant Madame de Bury's request that an officer in the Indian Army be promoted by Richard Airey (1860), a description of his house in China by James Bruce Elgin (1860) and a discussion of French politics and her newly-married life in the country by Frances [i.e. Fanny] Burney (1792).

Books on Arabic and Persian languages, and on the history and antiquities of Arabia, Iraq and the Near East that formed part of Gertrude Bell's working library.

Part of a bequest from Edwin Clarke (1919-1996), the Clarke Local Collection is more than a local history collection as it is quite strong in the literature of the region too: T. Wilson's The pitman's pay: and other poems (1843), Robert White's The Tynemouth nun: a poem (1829), Rhymes of Northern bards (1812) and more, as well as memoirs, sermons, topographical descriptions, guides and histories.

Although it comprises books published in the mid- to late-Twentieth Century, for the most part, it does contain a significant amount of more historic material, such as The papers which passed at New-castle betwixt his sacred Majestie and Mr Al. Henderson … (1649), R. Gardiner's Englands grievance discovered … (1655), A sentimental tour through Newcastle (1794), History of the water supply of Newcastle-upon-Tyne (1851) and several nineteenth-century directories and poll books.

Bequeathed by Edwin Clarke (1919-1996), approximately half of the Clarke Miscellaneous Collection was published in the Twentieth Century but the collection contains material dating back to 1655. It is a collection with a strong bias towards the occult, ritual and folklore, with some rogue items relating to book history.

Examples include A laconic narrative on the life & death of James Wilson, known by the name of Daft Jamie (1881) - a victim of Burke and Hare -, F. Hutchinson's An historical essay concerning witchcraft (1718), The Yorkshire spiritual telegraph and British harmonial advocate (1857) and a book on exercise by H. Halsted called Motion-life: or the demon of the age and means of its exorcism (1856).