The Miscellaneous Manuscripts include some local history material, particularly relating to nineteenth-century bonds and deeds and to the coal trade as well as A collection of recipes, compiled in the years 1684-5; agriculturalist Robert Bakewell's Letters to George Culley, 1786-1792; eighteenth-century household account books; manuscript letters from Henry Liddell on the 1715 Jacobite Rebellion; early twentieth-century National Service League memoranda; An alphabetical list of members of the Northumberland Militia enrolled between 1809 and 1813, giving their full names, places of residence, trades, ages, dates of enrolment, and parishes for which installed; a fair copy of poems by Mary Coleridge, bound in vellum, which she made for a friend in 1891 and which was later published as Fancy's Following; worksheets, correspondence, typescripts and a postcard relating to Tony Harrison's Newcastle is Peru and letters from Sean O'Casey to the People's Theatre, Newcastle.

The Bradshaw Collection contains books published 1601-1700 and is notable for its English Revolution, or Civil War, tracts, of which there are about sixty mostly describing local events, such as The Taking of Gateshead Hill: and blocking up of Newcastle … (1644), A Terrible and bloudy fight at Tinmouth Castle on Fryday last … (1648) and The King's declaration at Newcastle concerning his refusall to come to the parliament of England … (1647). Some of these are illustrated, often with wood-cut portraits.Other subjects represented in the collection include theology and some literature. Classical works, in Latin and Greek, by such authors as Catullus, Pliny, Virgil and Juvenal; Aristophanes, Dionysius and Euripides make up a large portion of the collection. The collection also has volume I of Edmund Gibson's English translation of William Camden's Britannia (1695), the first (Latin) edition of which had been the first comprehensive study of Britain.

This small collection comprises books which were produced in the infancy of the art of printing, and specifically before 1500. The collection includes such works as the Epistolae of St. Jerome, printed in Palma in 1480, Opus de peste, a tract on plague printed in Bologna in 1478, and the first printed book on architecture, Alberti's De Re Aedificatoria (1485).

The 17th Century Collection is a small but expanding collection of books printed 1600-1699. The books it contains are a good reflection of this period as a time of rebellions, intrigues and conspiracies; hierarchical power; and strong religious views. Sermons and speeches were commonly printed.

Contains of 2 albums of letters, including some by people of local significance like Thomas Bewick, Richard Grainger, George Stephenson, George Otto Trevelyan, Robert Spence Watson and Joseph Swan and others written by such household names as A.E. Houseman, Horatio Nelson, Isambard Kingdom Brunel, William Wilberforce, Michael Faraday, William Ewart Gladstone, Thomas Carlyle, Walter Besant, Mary Shelley, Charles Babington, Garibaldi, Victor Hugo, Ellen Terry and Robert Southey. Other letters include a request for an address to facilitate the delivery of a bear skin from David Walton (1859), an account of the pranks of the 'Borrowlow Bogle' from J. Arkle (1856), the refusal to grant Madame de Bury's request that an officer in the Indian Army be promoted by Richard Airey (1860), a description of his house in China by James Bruce Elgin (1860) and a discussion of French politics and her newly-married life in the country by Frances [i.e. Fanny] Burney (1792).

The Entomology Collection currently contains books on insects which were published between the late-Eighteenth and mid-Nineteenth Centuries, some of which have hand-coloured illustrations. The books are written in English, French or German, for the most part, with some in Latin.

The 18th Century Collection contains approximately 4000 volumes printed 1700-1799. The collection covers a variety of subjects including aspects of the penal system, education and the constitution. Highlights include the famous treatise by the English philosopher and enlightenment thinker John Locke, Some thoughts concerning education ( 1772) in which Locke applies his theories of the self and the mind to approaches to education and The state of the prisons in England and Wales: with preliminary observations and an account of some foreign prisons and hospitals (1784) by the English philanthropist and prison reformer John Howard, detailing his findings after visiting several hundred prisons across England, Scotland and Wales, in a series of reports, maps and plans.

This is a collection of over 2000 volumes and hundreds of pamphlets, covering the history of medicine and a broad range of medical subjects. The collection is rich in seventeenth, eighteenth and nineteenth-century works.

It includes books from the medical library of noted South Shields doctor T.M. Winterbottom (1766-1859), and highlights include Erasmus Darwin's Zoonomia (1794), John Abercrombie's Pathological and Practical Researches on Diseases of the Brain and Spinal Cord (1828), considered to have been the first textbook on Neuropathology, and several works by the famed botanist, humanist and physician Herman Boerhaave (1668-1738).

The Bradshaw-Bewick Collection contains works by and relating to the engraver Thomas Bewick (1753-1828). Bewick was born at Cherryburn, near Mickley, Northumberland and his early interest in drawing, under the tuition of the Reverend C. Gregson, was later developed when he was apprenticed under the Newcastle engraver, Ralph Beilby. He was to become a master craftsman.Bewick had a particular fascination with the natural world and this is reflected in works such as A general history of quadrupeds (1790) and History of British birds (1797). The collection is strong in Bewick's other main area of interest - morals and fables. His Select fables (1784) was immediately popular and ran into several editions but he worked on many small moral instruction books, such as Youth's instructive and entertaining story-teller (1778) and The looking-glass for the mind (1792).

The 19th Century Collection of books published 1800-1899, is broad in subject coverage but English literature is well-represented with works by such authors as R. Browning, A. Tennyson, D.G. Rossetti, C. Dickens, G. Crabbe, C.A. Swinburne, G. Meredith, R. Kipling and G. Eliot in the collection, as well as works by some lesser-known nineteenth-century writers and some nineteenth-century editions of earlier works.The collection includes first editions of Lewis Carroll's last novel for children, Sylvia and Bruno (1899), and of The Hunting of the Snark (1876). There is also local history material, such as local auction catalogues and C. Hindley's The history of the Catnach Press: at Berwick-upon-Tweed, Alnwick, and Newcastle-upon-Tyne, in Northumberland, and Seven Dials, London (1887) and some general history, natural history, travel accounts and nineteenth-century editions of Ancient Greek and Latin classical works.