This is a collection of over 2000 volumes and hundreds of pamphlets, covering the history of medicine and a broad range of medical subjects. The collection is rich in seventeenth, eighteenth and nineteenth-century works.

It includes books from the medical library of noted South Shields doctor T.M. Winterbottom (1766-1859), and highlights include Erasmus Darwin's Zoonomia (1794), John Abercrombie's Pathological and Practical Researches on Diseases of the Brain and Spinal Cord (1828), considered to have been the first textbook on Neuropathology, and several works by the famed botanist, humanist and physician Herman Boerhaave (1668-1738).

The Merz Collection is the mathematical library of John Theodore Merz (1840-1922), an electrical engineer. Merz also had an interest in philosophy, and the collection also includes books amassed by him during the writing of his work The History of European Thought in the Nineteenth Century. These 4000 volumes are strongest in Mathematics and the History of European Thought, but also include notable works on science, European history and German Literature.A particular highlight is An investigation of the laws of thought: on which are founded the mathematical theories of logic and probabilities (1854) by George Boole, the English mathematician and philosopher, and inventor of Boolean logic, the basis of modern digital computer logic.The collection is also of interest for its book-bindings: mostly leather or half-leather bindings by Zaehnsdorf of London.

The Miscellaneous Manuscripts include some local history material, particularly relating to nineteenth-century bonds and deeds and to the coal trade as well as A collection of recipes, compiled in the years 1684-5; agriculturalist Robert Bakewell's Letters to George Culley, 1786-1792; eighteenth-century household account books; manuscript letters from Henry Liddell on the 1715 Jacobite Rebellion; early twentieth-century National Service League memoranda; An alphabetical list of members of the Northumberland Militia enrolled between 1809 and 1813, giving their full names, places of residence, trades, ages, dates of enrolment, and parishes for which installed; a fair copy of poems by Mary Coleridge, bound in vellum, which she made for a friend in 1891 and which was later published as Fancy's Following; worksheets, correspondence, typescripts and a postcard relating to Tony Harrison's Newcastle is Peru and letters from Sean O'Casey to the People's Theatre, Newcastle.

The papers of Mary Caroline Moorman (1905-1994), historian, biographer and daughter of the historian G.M. Trevelyan, cover the years 1872-1992. As well as usefully supplementing the Trevelyan Archives at Newcastle University Library, they are of considerable interest in themselves.

They mainly consist of letters from Mary Moorman's parents, George M. Trevelyan and Janet Penrose Trevelyan, née Ward. They also include some letters from Mary Moorman's extended family, such as Janet Ward's mother, the novelist Mary Augusta (Mrs. Humphry) Ward, her sister Dorothy and the Philips and Price relatives.

The Napoleon Collection contains books written in French as well as English language materials, published in the Twentieth Century with the exception of three nineteenth-century items. The books relate to Napoleon (1769-1821), the Napoleonic Wars and to the French empire and include 'notes and reminiscences' as well as histories.

Newcastle University evolved from two colleges founded in the Nineteenth Century as part of the University of Durham, the School of Medicine and Surgery (established in 1834) and Durham College of Science (established in 1871, became Armstrong College in 1904). In 1937, the Newcastle Colleges became King's College and achieved independence from the University of Durham in 1963 when it became the University of Newcastle upon Tyne.The University Archive contains significant material relating to the development of Newcastle University and its predecessors. It includes Annual Reports, Senate and Council minutes and departmental publications covering many subjects.