This is a collection of chiefly historical medical texts, numbering about 450 volumes, along with some archival material which was formerly owned by the neurologist and medical historian, Edwin Clarke (1919-1996). The collection usefully complements the Pybus and the Medical Collections.

Highlights include An inquiry concerning the history of the cowpox: principally with a view to supersede and extinguish the smallpox (1798) by George Pearson, the well-known physician, chemist and early advocate of Jenner's cowpox vaccination; and the Report from the Committee appointed to examine the physicians who have attended His Majesty, during his illness: touching the present state of His Majesty's health (1789), issued by Parliament during the period of King George III's recurrent mental illness. The collection also contains some modern secondary texts on various aspects of the history of medicine.

This is a collection of over 2000 volumes and hundreds of pamphlets, covering the history of medicine and a broad range of medical subjects. The collection is rich in seventeenth, eighteenth and nineteenth-century works.

It includes books from the medical library of noted South Shields doctor T.M. Winterbottom (1766-1859), and highlights include Erasmus Darwin's Zoonomia (1794), John Abercrombie's Pathological and Practical Researches on Diseases of the Brain and Spinal Cord (1828), considered to have been the first textbook on Neuropathology, and several works by the famed botanist, humanist and physician Herman Boerhaave (1668-1738).

The Pybus Collection, originally brought together by the esteemed local medic and surgeon Professor Frederick Charles Pybus (1883-1975), is rich in material relating to the history of medicine. The collection consists chiefly of some 2000 volumes which are mostly classics of the history of medicine, with particular reference to anatomy, surgery and medical illustration.

Highlights are Gilles de Corbeil's De Pulsibus (1494), the first printed book on the pulse, as well as a 1648 edition of William Harvey's celebrated work Exercitatio anatomica de motu cordis et sanguinis in which he published his discoveries about the motion of the heart and blood. There is also a 1555 edition of one of the most important and influential books in the history of medicine, De Humani Corporis Fabrica by Andreas Versalius. Most of the other celebrated anatomists are represented here too, as well as later pioneers and experts.

The Pybus collection also includes engravings, portraits, busts, holographic letters and a set of bleeding bowls (currently housed at the Walton Library).