Newcastle University evolved from two colleges founded in the Nineteenth Century as part of the University of Durham, the School of Medicine and Surgery (established in 1834) and Durham College of Science (established in 1871, became Armstrong College in 1904). In 1937, the Newcastle Colleges became King's College and achieved independence from the University of Durham in 1963 when it became the University of Newcastle upon Tyne.The University Archive contains significant material relating to the development of Newcastle University and its predecessors. It includes Annual Reports, Senate and Council minutes and departmental publications covering many subjects.

The Napoleon Collection contains books written in French as well as English language materials, published in the Twentieth Century with the exception of three nineteenth-century items. The books relate to Napoleon (1769-1821), the Napoleonic Wars and to the French empire and include 'notes and reminiscences' as well as histories.

The Miscellaneous Manuscripts include some local history material, particularly relating to nineteenth-century bonds and deeds and to the coal trade as well as A collection of recipes, compiled in the years 1684-5; agriculturalist Robert Bakewell's Letters to George Culley, 1786-1792; eighteenth-century household account books; manuscript letters from Henry Liddell on the 1715 Jacobite Rebellion; early twentieth-century National Service League memoranda; An alphabetical list of members of the Northumberland Militia enrolled between 1809 and 1813, giving their full names, places of residence, trades, ages, dates of enrolment, and parishes for which installed; a fair copy of poems by Mary Coleridge, bound in vellum, which she made for a friend in 1891 and which was later published as Fancy's Following; worksheets, correspondence, typescripts and a postcard relating to Tony Harrison's Newcastle is Peru and letters from Sean O'Casey to the People's Theatre, Newcastle.

This is a collection of over 2000 volumes and hundreds of pamphlets, covering the history of medicine and a broad range of medical subjects. The collection is rich in seventeenth, eighteenth and nineteenth-century works.

It includes books from the medical library of noted South Shields doctor T.M. Winterbottom (1766-1859), and highlights include Erasmus Darwin's Zoonomia (1794), John Abercrombie's Pathological and Practical Researches on Diseases of the Brain and Spinal Cord (1828), considered to have been the first textbook on Neuropathology, and several works by the famed botanist, humanist and physician Herman Boerhaave (1668-1738).

Contains of 2 albums of letters, including some by people of local significance like Thomas Bewick, Richard Grainger, George Stephenson, George Otto Trevelyan, Robert Spence Watson and Joseph Swan and others written by such household names as A.E. Houseman, Horatio Nelson, Isambard Kingdom Brunel, William Wilberforce, Michael Faraday, William Ewart Gladstone, Thomas Carlyle, Walter Besant, Mary Shelley, Charles Babington, Garibaldi, Victor Hugo, Ellen Terry and Robert Southey. Other letters include a request for an address to facilitate the delivery of a bear skin from David Walton (1859), an account of the pranks of the 'Borrowlow Bogle' from J. Arkle (1856), the refusal to grant Madame de Bury's request that an officer in the Indian Army be promoted by Richard Airey (1860), a description of his house in China by James Bruce Elgin (1860) and a discussion of French politics and her newly-married life in the country by Frances [i.e. Fanny] Burney (1792).

This small collection comprises books which were produced in the infancy of the art of printing, and specifically before 1500. The collection includes such works as the Epistolae of St. Jerome, printed in Palma in 1480, Opus de peste, a tract on plague printed in Bologna in 1478, and the first printed book on architecture, Alberti's De Re Aedificatoria (1485).

The Entomology Collection currently contains books on insects which were published between the late-Eighteenth and mid-Nineteenth Centuries, some of which have hand-coloured illustrations. The books are written in English, French or German, for the most part, with some in Latin.

The Bradshaw-Bewick Collection contains works by and relating to the engraver Thomas Bewick (1753-1828). Bewick was born at Cherryburn, near Mickley, Northumberland and his early interest in drawing, under the tuition of the Reverend C. Gregson, was later developed when he was apprenticed under the Newcastle engraver, Ralph Beilby. He was to become a master craftsman.Bewick had a particular fascination with the natural world and this is reflected in works such as A general history of quadrupeds (1790) and History of British birds (1797). The collection is strong in Bewick's other main area of interest - morals and fables. His Select fables (1784) was immediately popular and ran into several editions but he worked on many small moral instruction books, such as Youth's instructive and entertaining story-teller (1778) and The looking-glass for the mind (1792).

The Bradshaw Collection contains books published 1601-1700 and is notable for its English Revolution, or Civil War, tracts, of which there are about sixty mostly describing local events, such as The Taking of Gateshead Hill: and blocking up of Newcastle … (1644), A Terrible and bloudy fight at Tinmouth Castle on Fryday last … (1648) and The King's declaration at Newcastle concerning his refusall to come to the parliament of England … (1647). Some of these are illustrated, often with wood-cut portraits.Other subjects represented in the collection include theology and some literature. Classical works, in Latin and Greek, by such authors as Catullus, Pliny, Virgil and Juvenal; Aristophanes, Dionysius and Euripides make up a large portion of the collection. The collection also has volume I of Edmund Gibson's English translation of William Camden's Britannia (1695), the first (Latin) edition of which had been the first comprehensive study of Britain.