This is a collection of chiefly historical medical texts, numbering about 450 volumes, along with some archival material which was formerly owned by the neurologist and medical historian, Edwin Clarke (1919-1996). The collection usefully complements the Pybus and the Medical Collections.

Highlights include An inquiry concerning the history of the cowpox: principally with a view to supersede and extinguish the smallpox (1798) by George Pearson, the well-known physician, chemist and early advocate of Jenner's cowpox vaccination; and the Report from the Committee appointed to examine the physicians who have attended His Majesty, during his illness: touching the present state of His Majesty's health (1789), issued by Parliament during the period of King George III's recurrent mental illness. The collection also contains some modern secondary texts on various aspects of the history of medicine.