Conisists of 30 minute panel discussion programme presented by Andrew Marr, featuring Sir Liam, novelist William Boyd, broadcaster John Micklethwait, and journalist Polly Toynbee. Each offers predictions for the coming years; Sir Liam's being the inevitably of another influenza pandemic. Discusses historical trends, the need for good planning to mitigate harm, public and political reactions to pandemics, and what the UK is doing to prepare.

Other health issues discussed include stem cell research, Sir Liam's perception of the strengths and weaknesses of the NHS and reforms during his time as Chief Medical Officer, and the 'Nanny State' in relation to healthy lifestyles.